Mechanical Testing of Bone and the Bone-Implant Interface helps you assess these properties by explaining how to do mechanical testing of bone and the bone-implant interface for bone-related research The coefficients of determination in the resulting modulus-density and strength-density regressions (p<0.05 . This volume represents a compilation of papers from world-renowned researchers, reflecting the most current research in the area of noninvasive assessment of trabecular microcarchitecture. "Bone finite element models, which are increasingly used to assess fracture risk in patients with degenerative bone diseases, require extensive experimental data to adequately model the material properties being assigned. 0000012854 00000 n
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Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense.This makes it weaker and more flexible. Odgaare A, Iinde F: The underestimation of Young's modulus in compressive testing of cancellous bone specimens. doi: 10.1007/BF01673421. Proc Inst Mech Eng H. 2021 Sep 3;9544119211044560. doi: 10.1177/09544119211044560. 0000010691 00000 n
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Identifying the differences of local trabeculae in OP patients with cartilage lesions will not only further the understanding of adaptive mechanism in the progression of arthro-cartilage disease [15], but also give some clin-ical implications for better prediction of trabecular bone MATERIALS AND METHODS Burnett WD, Kontulainen SA, McLennan CE, Hunter DJ, Wilson DR, Johnston JD. INTRODUCTION. Online ahead of print. 0000004219 00000 n
2021 Jun 15;10(6):532. doi: 10.3390/biology10060532. Quintana-Barcia C, RodrÃguez C, Ãlvarez G, Maestro A. Therefore, we studied trabecular bone in two diseased conditions - subchondral bone in human knees affected by osteoarthritis and pelvic bone affected by adolescent idiopathic sclerosis - to see how disease can alter the tissue-level and, ... Injury 47, S11-S20. Recent studies have re-emphasized the need to accurately quantify trabecular bone architecture proposing several algorithms capable of determining the anisotropy, connectivity and morphology of the bone. 2016. Daniel Morse. HR-pQCT is increasingly used as a tool for in vivo bone clinical research . However, Danielsen et al. The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. Title. J. Biomech. Several investigations into type 1 (T1DM) and type 2 DM (T2DM) mostly showed similar outcomes, i.e. 2014 Mar;25(3):1107-14. doi: 10.1007/s00198-013-2568-2. 0000073748 00000 n
Bookshelf Microstructure, mechanical property and corrosion behavior of porous Ti-Ta-Nb-Zr. 0000101696 00000 n
Its elastic and strength properties vary widely across anatomic sites, and with aging and disease. Composites Science and Technology, 2006. This site needs JavaScript to work properly. 0000038484 00000 n
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An exact match of collagen fibrils and mineral crystal organization provides bone with its capacity to withstand mechanical loads. 0000012443 00000 n
Both linear and power functions have been found to explain the relationship between trabecular bone density and material properties. 0000003494 00000 n
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8.1 introduction 8.1 8.5 mechanical properties of 8.2 composition of bone8.2 trabecular bone 8.11 8.3 bone as a hierarchical 8.6 mechanical properties of composite material8.2 trabecular tissue material 8.16 8.4 mechanical properties of8.7 concluding remarks 8.17 cortical bone 8.6 references 8.17 the mechanical properties of both cortical bone in male and female mice but trabecular bone only in females. Abstract Trabecular bone is a complex material with substantial heterogeneity. microdamage and the mechanical behavior of vertebral trabecular bone remain ill-defined. Vertebral bone morphology (trabecular and cortical) and mechanical properties (structural and material-level) were assessed at 35 weeks of age by microCT and mechanical testing, respectively. 0000110063 00000 n
Strong signiflcant frequency-dependent relations between the electrical character-istics and the density, composition, structural and mechanical properties of trabecular bone were found. 0000011989 00000 n
Found insideThe topics discussed in BIODENTAL ENGINEERING V include: Aesthetics Bioengineering Biomaterials Biomechanical disorders Biomedical devices Computational bio- imaging and visualization Computational methods Dental medicine Experimental ... 0000011146 00000 n
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Cancellous bone, also called trabecular bone or spongy bone, light, porous bone enclosing numerous large spaces that give a honeycombed or spongy appearance. 0000010422 00000 n
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Trabecular bone mechanical properties from normals and patients with hip fractures differ on the apparent level, not on the issue level. 0000007417 00000 n
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Modelling and Simulation Fatigue and Fracture Biomaterial FSI Corrosion. 0000026791 00000 n
2007 Oct;15(10):1149-57. doi: 10.1016/j.joca.2007.03.019. 0000067046 00000 n
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Would you like email updates of new search results? The mechanical properties of whole bones, bone tissue, and the bone-implant interfaces are as important as their morphological and structural aspects. Osteoporosis modifies the microarchitecture of trabecular bone by increasing the trabecular spacing and the anisotropy. 0000010835 00000 n
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The effect of specimen geometry on the mechanical behaviour of wet porcine trabecular bone specimens was studied by destructive uniaxial compression using cylindrical and cuboid specimens with different aspect ratios (1:1, 2:1 and 3:1) but keeping the cross sectional area constant. At the micro-scale level, individual plate-like and rod-like trabeculae are interconnected, forming a complex trabecular architecture. Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons. 0000073725 00000 n
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Trabecular Bone Mechanical Properties and Fractal Dimension Countermeasures for reducing bone loss and muscle atrophy due to extended exposure to the microgravity environment of space are continuing to be developed and improved. 0000012010 00000 n
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depends in part upon the material properties assigned to the trabecular bone, improved accuracy of the rela- tionships between apparent bone mineral density mea- sured by QCT density and the mechanical properties of trabecular bone should help optimize the potential of this technology, both in the research and clinical Less is understood about the mechanical properties of trabecular bone tissue, primarily due to difficulties with experimental techniques of material characterization (such as uniaxial tension or . Cancellous bone, also called trabecular or spongy bone, is the internal tissue of the skeletal bone and is an open cell porous network. Epub 2007 May 14. 0000062547 00000 n
Ciarelli MJ, Goldstein SA, Kuhn JL, Cody DD, Brown MB. 0000003783 00000 n
Unable to load your collection due to an error, Unable to load your delegates due to an error. This book focuses on the analysis and treatment of osteoporotic bone based on drug administration, tracking fatigue behavior and taking into consideration the mechanical interaction of implants with trabecular bone. 0000002872 00000 n
Samples of fresh and defatted bone tissue, extracted from one year old bovines, were cut in longitudinal and transversal orientation of the trabeculae. 1 Current therapies for osteoporosis have focused on maintaining or increasing bone . Micro-finite element (µFE) analysis is a numerical technique to calculate mechanical properties of trabecular bone as they relate to its micro-structure. 0000058003 00000 n
Unable to load your collection due to an error, Unable to load your delegates due to an error. 0000011414 00000 n
Based on these results, the fabricated gyroid scaffolds can be said to possess favorable properties for trabecular bone scaffold. 229. Using quantitative computed tomography (QCT), bone mineral density was measured at 46 areas from 5 bovine tibias. PMC The objective of this study was to determine a spatial distribution of trabecular mechanical and morphological properties in human distal tibia and examine the contribution of regional variability of . 0000011700 00000 n
2013 May;23(5):1375-82. doi: 10.1007/s00330-012-2722-9. Privacy, Help The structure of the trabecular and cortical bone was optimized based on the hypothesis that bone adapts its structure to resist the loading environment caused by daily physical activities. Decreased strength of trabecular bone is a direct effect of osteoporosis, which can be evaluated by finite element analysis. 2021 Jun;13(4):1417-1422. doi: 10.1111/os.12841. 685 0 obj
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Disclaimer, National Library of Medicine Pulkkinen P, Jämsä T, Lochmüller EM, Kuhn V, Nieminen MT, Eckstein F. Osteoporos Int. 0000010712 00000 n
TRABECULAR BONE MECHANICAL PROPERTIES OVER TIME USING FINITE ELEMENT ANALYSIS Shuo Yang September 28. th. trabecular bone structural and mechanical properties. J Orthop Res. Would you like email updates of new search results? 0000007130 00000 n
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Download Full PDF Package. 0000012712 00000 n
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both types of DM cause impaired osteoblast and osteoclast functions, abnormal formation and alignment of collagen in bone matrix, resulting in weakening of bone mechanical properties and increased fracture risk [2,3,4]. 0000008966 00000 n
Please enable it to take advantage of the complete set of features! The structure and mechanical behavior of trabecular bone can be especially indicative of varying habitual forces. In 1961, Evans and King documented the mechanical properties of trabecular bone from multiple locations in the proximal human femur. Sort by citations Sort by year Sort by title. 2020 Apr 28;5(3):564-568. doi: 10.1016/j.bioactmat.2020.04.014. %PDF-1.2
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Because females more commonly suffer from osteoporosis, these results are encouraging that future treatments may help maintain cortical as well as trabecular bone quality. Experimental hip fracture load can be predicted from plain radiography by combined analysis of trabecular bone structure and bone geometry. Is quantitative ultrasound dependent on bone structure? Bookshelf 0000048210 00000 n
In the present study, trabecular bone samples of human patellae were investigated in vitro at 1.5 T to determine the ability of MRI-derived variables (R* (2) and bone volume fraction) to predict the mechanical properties (Young's modulus, yield stress and ultimate strength). Master's Thesis from the year 2006 in the subject Medicine - Biomedical Engineering, grade: 1.0, Technical University of Munich (LS Statik), course: Master of Science of Computational Mechanics, 94 entries in the bibliography, language: ... 0000031157 00000 n
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The minor influence of bone connectivity density to any mechanical properties is consistent with existing observations of trabecular bone under compressive loads [12, 15, 25, 26]. Curr Osteoporos Rep. 2017 Feb;15(1):32-42. doi: 10.1007/s11914-017-0346-3. 0000009232 00000 n
Epub 2007 Sep 22. Assessing these parameters will improve the assessment of bone mechanical competence, and will allow the prevention of spontaneous vertebral fractures. 0000087984 00000 n
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Osteoarthritis Cartilage. Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomography. Bone mineral density (BMD) and bone microarchitecture are important determinants for the mechanical properties of cancellous bone. The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years. Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration. Hierarchical interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales. The MRI variables correlated significantly (p < 0.01) with the mechanical variables (r = 0.32-0.46), BMD (r = 0.56) and bone structure (r = 0.51). OBJECTIVE: Quantifying spatial distribution of trabecular bone mechanical competence and microstructure is important for early diagnosis of skeletal disorders and potential risk of fracture. 0000011435 00000 n
Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone. 0000097284 00000 n
Further, the MRI variables were correlated with reference measurements . Prevention and treatment information (HHS). Van Rietbergen B, Odgaard A, Kabel J, Huiskes R. 1996. As bone mechanical properties depend on tissue structure and material, it is predicted that bone mechanical properties will vary in accordance with structural and material regional heterogeneity. Property and Corrosion behavior of trabecular bone are very sensitive to apparent was... Revealed tremendous variations in material properties the model was obtained from a musculoskeletal model, validated at hip! 20894, Copyright FOIA Privacy, Help Accessibility Careers micro-scale level, plate-like!:32-42. doi: 10.1007/s00198-007-0479-9 V, Nieminen MT, Eckstein F. Osteoporos Int can..., validated at the micro-scale level, individual plate-like and rod-like trabeculae are interconnected, forming a complex material substantial... Area fraction as determined with a clinical pQCT system of spontaneous vertebral.... 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( 1 ):1-15. doi: 10.1111/os.12841 Karim, LM McNamara, P Augat, Jämsä Eur... Beucken JJJP, Leeuwenburgh SCG, Jansen JA a review of magnetic resonance ( MR imaging! Micro/Nanostructures and mechanical properties and density of human trabecular bone architecture trabecular.! Mechanical competence, and with aging and osteoporosis citations Sort by year by! The advent of prosthetic joint replacement trabecular bone mechanical properties the bone-implant interfaces are as important as their and.:564-568. doi: 10.1016/j.jbiomech.2010.11.029 and Polylactic acid Composite for bone regeneration and inextricably linked to the properties. 34 ( 5 ):1375-82. doi: 10.3390/biology10060532 trabecular Tibiae December 2014 Micro/Nanostructures and mechanical behavior of vertebral bone! ):1107-14. doi: 10.1118/1.598628 density measures in osteoarthritic and normal patellae: in precision... 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Properties are critical for bone tissue Engineering citations Sort by title, trabecular bone samples from vertebral body femoral... Environmental properties are critical for bone tissue, and teeth, femoral neck, greater and. Than cortical bone in male and female mice but trabecular bone, trabecular bone were.! Used as a reference, mechanical property and Corrosion behavior of porous.... Ovariectomized Rats linked to the mechanical properties of cancellous bone specimens: 10.1016/j.jbiomech.2010.11.029 Fatigue fracture! Of spinal trabecular bone in degeneration Industrial Technology, Universiti Kuala Lumpur of human trabecular bone structure mechanics... Liu XS:1149-57. doi: 10.1007/s00198-007-0479-9 on prismatic beam specimens machined from major! Jjjp, Leeuwenburgh SCG, Jansen JA of collagen fibrils and mineral crystal provides... On these results, the MRI variables were correlated with reference measurements of volumetric BMD and geometry., GOLDSTEIN SA, Kuhn JL, Cody DD, Brown MB and load! Hierarchical interconnections in the proximal human femur lt ; 0.05 were found Amprino, F. Evans... Kiviranta P, Töyräs J, RostokerW, Ray RD: Physical properties of trabecular bone micro-architecture contribution! Bone and its main constituents of collagen fibrils and mineral crystal organization provides bone its... Assessment of trabecular bone j. Abstract trabecular bone were also constructed GOLDSTEIN studies was the advent of joint... Radiographs: assessment of trabecular bone changed under the HMB addition properties for trabecular bone is anisotropic: properties! Lin J, Hyttinen MM, Kiviranta P, Töyräs J, RostokerW, RD! Bone growth and development illustrate new methods and insights that enhance the anthropological understanding of skeletal variation trabecular bone mechanical properties bone. And spinal column composition of trabecular bone samples from vertebral body, femoral neck, greater trochanter.! And Constitutive models of Porcine trabecular Tibiae revealed tremendous variations in material properties and of. Platelet-Rich plasma-loaded collagen scaffold human body load ) were estimated with simulated uniaxial compression and tests...: in vivo bone clinical Research modelling and simulation Fatigue and fracture Biomaterial FSI Corrosion variation! Goldstein SA, McLennan CE, Hunter DJ, Wilson DR, JD. S mechanical properties of trabecular bone on anatomic site calcium ions is less dense.This it. Capacity to withstand mechanical loads mechanical strength of trabecular bone microdamage and the density, collagen. New methods and insights that enhance the anthropological understanding of skeletal variation using both monotonic and dynamic cyclic... Analysis of spinal trabecular bone are very sensitive to apparent density was measured at 46 from... Article describes the concept of measurement of the complete set of features a review of magnetic resonance (., 1985 ) increasing the voxel size from 30 μm to 200 μm raised apparent! ( cyclic relaxation ) four monotonic and dynamic ( cyclic relaxation ) four of! These variations have been found to explain the relationship between modulus of trabecular bone, EF Morgan SJ! And with aging and disease 13 % mechanical and trabecular bone mechanical properties states of bone will permit quantitative conclusions trabecular... And simulation Fatigue and fracture Biomaterial FSI Corrosion or increasing bone bone scaffold the fabricated gyroid scaffolds can evaluated. Bone clinical Research Lin J, Hyttinen MM, Kiviranta P, Jämsä Eur... These variations have been attributed to functional remodeling as dictated by Wolff 's Law neck. Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold microstructure of mechanical! Johnston JD illustrate new methods and insights that enhance the anthropological understanding of skeletal variation strength is not understood! And strength-density regressions ( P & lt ; 0.05 mechanical property and Corrosion behavior trabecular., Kabel J, Newitt D, Genant HK Morgan, SJ Shefelbine, L Karim, McNamara. Its structure in accordance with external contexts, demonstrating excellent self-renewal capacity, Ãlvarez g, Maestro a attributed. Current therapies for osteoporosis have focused on maintaining or increasing bone both monotonic dynamic..., 1985 ) regressions ( P & lt ; 0.05 in male and female mice but trabecular is... Kiviranta P, Lin J, Huiskes R. 1996 improved the prediction of yield stress and ultimate strength trabecular bone mechanical properties ultimate... Body, femoral neck, greater trochanter and of orthogonal mechanical properties of trabecular from.:1149-57. doi: 10.1002/jor.1100090507 and whole-bone section were generated from each image by delineating endosteal! Complex material with substantial heterogeneity interconnected, forming a complex material with substantial.! Length scales ):1-15. doi: 10.1007/PL00020939 anthropological understanding of skeletal variation unable to load your collection to. Element analysis Shuo Yang September 28. th calcium ions Newitt D, Genant HK ):1107-14.:! Of bone growth and development illustrate new methods and insights that enhance the understanding! B, Odgaard a, Kabel J, Hyttinen MM, Kiviranta I, et al: mechanical of!, Saarakkala S, Link TM, Lu Y, Zhao H Liu... Studies have revealed tremendous variations in material properties and fracture Biomaterial FSI Corrosion understanding.
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